EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...
Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.
A growing cluster of laboratory and early clinical studies is testing whether injectable hydrogels, slow-release drug depots, ...
Scientists at the VIB–VUB Center for Structural Biology have uncovered a counterintuitive principle that could reshape how ...
BACKGROUND: Despite antiplatelet therapy, some patients remain at high ischemic risk because of drug nonresponsiveness or high residual platelet reactivity). We aimed to target an orphan platelet GPCR ...