Exploring mutations that spontaneously switch on a key brain cell receptor

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...

Unusual KRAS mutation in pancreatic cancer may explain less aggressive tumors

A study led by Aaron Hobbs, Ph.D., and Rachel Burge, Ph.D., at MUSC Hollings Cancer Center, reveals why a specific gene ...
Labroots

GoT-ChA! - Assessing How Mutations Affect DNA Structure in Single Cells

Scientists have created a new technique that can assess how mutations in the genome influence the packaging of DNA in cells. The genome is massive, and has to be carefully wrapped around proteins so ...
Hosted on MSN

Adaptive tracking theory of molecular evolution challenges mutation neutrality

For a long time, evolutionary biologists have thought that the genetic mutations that drive the evolution of genes and proteins are largely neutral: they're neither good nor bad, but just ordinary ...

Scientists identify pre-cancerous states in seemingly normal aging tissues

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the first time, in a study led by investigators at Weill Cornell Medicine and the ...

Shroom3 mutation linked to kidney scarring offers new drug target

Nearly 1 in 7 adults in the United States lives with chronic kidney disease, a condition that often advances quietly until serious damage has occurred. While diabetes and high blood pressure are ...
BioTechniques

Novel technique detects early DNA mutations

A new long-read sequencing technique has helped researchers investigate how DNA mutations arise in a variety of contexts. A collaboration of researchers led by NYU Langone Health and NYU Grossman ...
Nature

RAS cancer biology (mutations, signaling, etc.) plus emerging RAS-directed therapeutic advances and new horizons

The RAS family commonly drives the growth and survival of human cancers. Mutations in KRAS, NRAS, and HRAS occur in approximately 20% of all human cancers, including solid tumors, such as pancreatic, ...
BioTechniques

Novel tool for detecting hidden genetic mutations

A graph-based computational tool for detecting previously invisible genetic mutations has been developed. Researchers at the University of California, Los Angeles (UCLA; USA) and the University of ...
Labroots

A 'Junk DNA' Mutation That Prevents a Disease

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

New Data Underscoring Ability of Leapfrog Bio's OncoSLX Platform to Identify Drug Retargeting Opportunities for Treating Cancer Published in Nature Portfolio Journal

Study highlights importance of cancer driver biology in translating results from lab to patients -- -- Findings validate proprietary OncoSLX Platform (TM), a pharmacogenetic approach that captures the ...