How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the 1960s ...
DNA double-strand breaks (DSBs) represent one of the most deleterious forms of genetic damage, arising naturally during cellular replication or as a result of exposure to ionising radiation. The ...
A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...
Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...
A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...
Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...
Efficacy and safety data from Ph1b, dose optimization trial of two doses of TH1902 (sudocetaxel zendusortide), a novel SORT1-targeting peptide drug conjugate (PDC), administered weekly vs q3weekly in ...
NASA astronaut Nick Hague runs an analysis with the miniPCR hardware for Genes in Space-6 during Expedition 59. This experiment explored how space radiation damages DNA and how cells repair that ...
Researchers at Genentech Inc. and UC Davis have worked out the structure of the RAD51 complex, which repairs breaks in DNA. When DNA experiences a double-strand break, enzymes trim back one of the two ...
A day in the life of DNA can be rough. It gets yanked across a dividing cell, zapped by radiation, and assaulted by chemicals. Luckily, cells have developed a complex set of repair mechanisms to ...
New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.
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