A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive ...

Researchers explained to TPS-IL that the same genetic machinery that allows tumors to grow at extremely high speed may also ...

Scientific consensus on the biological mechanisms underpinning sunburn has remained largely unchanged for decades. The ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

The FDA has granted orphan drug designation (ODD) to LP-284, a next-generation acylfulvene small molecule, for the treatment ...

Deinococcus radiodurans is renowned for its extraordinary resistance to ionising radiation and other environmental stresses. This bacterium employs a combination of passive and active mechanisms to ...

Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

Researchers with McMaster University have discovered that the protein mutated in patients with Huntington's Disease doesn't repair DNA as intended, impacting the ability of brain cells to heal ...

Three biochemical steps of the non-homologous DNA end-joining (NHEJ) process. This figure outlines the key stages of the NHEJ repair mechanism following DNA double-strand breaks. The process can be ...

Greenland sharks possess a DNA repair mechanism that maintains vision over centuries, preventing retinal degeneration despite extreme conditions. The sharks' visual system is well-adapted to dim light ...